Hidradenoma Papilliferum
Senait W. Dyson, MD
David Cassarino, MD, PhD
Key Facts
Terminology
Well-circumscribed adenoma with apocrine differentiation
Clinical Issues
Rare, benign tumor
Vulvar or perianal area, predominately in women
Microscopic Pathology
Well-circumscribed, dermal-based tumor
No connections to the epidermis
Maze-like glandular spaces and papillary foldings
Apocrine differentiation is usually seen
Top Differential Diagnoses
Tubular apocrine adenoma
Syringocystadenoma papilliferum
Nipple adenoma
Papillary eccrine adenoma
Hidradenoma
 Hidradenoma papilliferum at low magnification shows a proliferation of papillary, cystic, and glandular areas with a complex, arborizing architecture. The tumors are dermal-based and well circumscribed. |
 Higher magnification of a hidradenoma papilliferum shows the elongated, arborizing papillary structures  lined by 2-3 cell layers of bland columnar luminal cells and underlying myoepithelial cells. |
TERMINOLOGY
Abbreviations
Hidradenoma papilliferum (HP)
Synonyms
Papillary hidradenoma
Definitions
Small, well-circumscribed, dermal-based adenoma with apocrine differentiation
CLINICAL ISSUES
Epidemiology
Incidence
Rare
Age
Adult
Gender
Almost always women
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