Hidradenoma Papilliferum
Senait W. Dyson, MD
David Cassarino, MD, PhD
Key Facts
Terminology
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Well-circumscribed adenoma with apocrine differentiation
Clinical Issues
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Rare, benign tumor
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Vulvar or perianal area, predominately in women
Microscopic Pathology
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Well-circumscribed, dermal-based tumor
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No connections to the epidermis
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Maze-like glandular spaces and papillary foldings
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Apocrine differentiation is usually seen
Top Differential Diagnoses
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Tubular apocrine adenoma
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Syringocystadenoma papilliferum
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Nipple adenoma
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Papillary eccrine adenoma
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Hidradenoma
Hidradenoma papilliferum at low magnification shows a proliferation of papillary, cystic, and glandular areas with a complex, arborizing architecture. The tumors are dermal-based and well circumscribed. |
Higher magnification of a hidradenoma papilliferum shows the elongated, arborizing papillary structures  lined by 2-3 cell layers of bland columnar luminal cells and underlying myoepithelial cells. |
TERMINOLOGY
Abbreviations
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Hidradenoma papilliferum (HP)
Synonyms
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Papillary hidradenoma
Definitions
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Small, well-circumscribed, dermal-based adenoma with apocrine differentiation
CLINICAL ISSUES
Epidemiology
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Incidence
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Rare
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Age
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Adult
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Gender
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Almost always women
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