Granulomatosis with Polyangiitis

Granulomatosis with Polyangiitis

Brian J. Hall, MD

Early gangrenous changes of the digits on the hand are present here secondary to granulomatous vasculitis of GPA.

This biopsy of cutaneous GPA shows extravascular fibrinoid material image, karyorrhexis image, RBC extravasation image, and fibrinoid necrosis of vessels image. (Courtesy K. Duffy, MD.)



  • Granulomatosis with polyangiitis (GPA)


  • Wegener granulomatosis, Wegener


  • Systemic disease characterized by generalized necrotizing angiitis of medium-sized blood vessels, necrotizing granulomas of upper and lower respiratory tract, and focal necrotizing glomerulonephritis



  • Thought to represent autoimmune inflammatory process or hypersensitivity reaction to possible unknown antigen(s)

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Granulomatosis with Polyangiitis

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