Fibrous Hamartoma of Infancy



Fibrous Hamartoma of Infancy


Elizabeth A. Montgomery, MD





Key Facts


Terminology



  • Benign superficial fibrous lesion occurring during 1st 2 years of life


Clinical Issues



  • Congenital in up to 25% of cases


  • M > F


  • Occurs in deep dermis or subcutis



    • Typically in upper torso, but at variety of sites


  • Complete excision curative



    • Can recur if incompletely excised


Microscopic Pathology



  • 3 components in organoid growth pattern



    • Intersecting bands of mature fibrous tissue, comprising spindle-shaped myofibroblasts and fibroblasts


    • Nests of immature round, ovoid, or spindle cells within loose stroma


    • Interspersed mature fat







H&E shows fibrous hamartoma of infancy. The lesion expands the deep dermis and superficial submucosa consisting of eosinophilic fibrous zones image, more basophilic areas image, and fat image.






This field shows the 3 key components of fibrous hamartoma of infancy. The so-called “primitive cells” are on the upper left image, intimately admixed with the fibrous image and fat image elements.

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Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Fibrous Hamartoma of Infancy

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