Appendix 1: Ovarian Tumors With Mucinous Epithelium
Primary Tumors
- ■
Surface epithelial tumors
- •
Mucinous cystic tumors of intestinal and endocervical-like type
- •
Surface epithelial tumors of mixed cell type with a mucinous component
- •
Mixed müllerian tumors (adenofibroma, adenosarcoma, MMMT a
a Malignant müllerian mixed tumor.
)
- •
Brenner tumors
- •
- ■
Germ cell tumors
- •
Teratomas (mature and immature)
- •
Mucinous and strumal carcinoid tumors
- •
- ■
Other
- •
Sertoli–Leydig cell tumor with heterologous elements
- •
Adult granulosa cell tumor b
b Mucinous epithelium in adult granulosa cell tumors is a rare finding.
- •
Small cell carcinoma of hypercalcemic type
- •
Metastatic Tumors
- ■
Mucinous carcinoma arising elsewhere in the female genital tract, especially the cervix
- ■
Mucinous carcinoma from the colon, appendix, small bowel, stomach, pancreas, biliary tract
- ■
Urinary bladder and urachus
- ■
Low-grade mucinous tumors from the appendix
Appendix 2: Ovarian Tumors That May Have an Endometrioid-Like Glandular Pattern
Primary Tumors
- ■
Endometrioid carcinoma
- ■
Mucin-poor mucinous adenocarcinoma
- ■
Endometrioid-like yolk sac tumor
- ■
Sertoli–Leydig cell tumor
- ■
Tumors of probable wolffian origin
- ■
Ependymomas
Metastatic Tumors
- ■
Endometrioid carcinoma arising elsewhere in female genital tract or endometriosis
- ■
Intestinal adenocarcinoma of typical and clear cell type
- ■
Other gastrointestinal, pancreatic, and biliary adenocarcinomas
- ■
Mucin-poor mucinous adenocarcinomas from other sites, e.g. lung
- ■
Breast carcinoma
- ■
Malignant mesothelioma
Appendix 3: Endometrioid Tumors of Ovary and Endometrium: Endometrial Primary and Ovarian Secondary Tumors
- 1.
Histologic similarity of the tumors
- 2.
Large endometrial tumor and small ovarian tumor(s)
- 3.
Atypical endometrial hyperplasia also present
- 4.
Deep myometrial invasion
- a.
Direct extension into adnexa
- b.
Vascular space invasion in myometrium
- a.
- 5.
Spread elsewhere in typical pattern of endometrial carcinoma
- 6.
Ovarian tumors, bilateral and/or multinodular
- 7.
Hilar location, vascular space invasion, surface implants, a
a Rare primary ovarian endometrioid carcinomas may arise from endometriosis on the ovarian surface.
or combination in ovary
- 8.
Ovarian endometriosis absent
- 9.
Aneuploidy with similar DNA indices or diploidy of both tumors b
b The possibility of tumor heterogeneity must be taken into account in the evaluation of the ploidy findings.
- 10.
Similar molecular genetic or karyotypic abnormalities in both tumors
Appendix 4: Endometrioid Tumors of Ovary and Endometrium: Ovarian Primary and Endometrial Secondary Tumors
- 1.
Histologic similarity of the tumors
- 2.
Large ovarian tumor and small endometrial tumor
- 3.
Ovarian endometriosis present
- 4.
Location in ovarian parenchyma
- 5.
Direct extension from ovary predominantly into outer wall of uterus
- 6.
Spread elsewhere in typical pattern of ovarian carcinoma
- 7.
Ovarian tumor unilateral (80–90% of cases) and forming single mass
- 8.
No atypical hyperplasia in endometrium
- 9.
Aneuploidy with similar DNA indices or diploidy of both tumors a
a The possibility of tumor heterogeneity must be taken into account in the evaluation of the ploidy findings.
- 10.
Similar molecular genetic or karyotypic abnormalities in both tumors
Appendix 5: Endometrioid Tumors of Ovary and Endometrium: Independent Ovarian and Endometrial Primary Tumors
- 1.
Histologic dissimilarity of the tumors
- 2.
No or only superficial myometrial invasion of endometrial tumor
- 3.
No vascular space invasion of endometrial tumor
- 4.
Atypical endometrial hyperplasia also present
- 5.
Absence of other evidence of spread of endometrial tumor
- 6.
Ovarian tumor unilateral (80–90% of cases)
- 7.
Ovarian tumor located in parenchyma
- 8.
No vascular space invasion, surface implants, a
a Rare primary ovarian endometrioid carcinomas may arise from endometriosis on the ovarian surface.
or predominant hilar location in ovary
- 9.
Absence of other evidence of spread of ovarian tumor
- 10.
Ovarian endometriosis present
- 11.
Different ploidy or DNA indices, if aneuploid, of the tumors b
b The possibility of tumor heterogeneity must be taken into account in the evaluation of the ploidy findings.
- 12.
Dissimilar molecular genetic or karyotypic abnormalities in the tumor
Appendix 6: Ovarian Tumors and Tumor-Like Lesions That May Contain Clear Cells
Primary Tumors
- ■
Clear cell carcinoma
- ■
Endometrioid carcinoma
- ■
Brenner tumor
- ■
Dysgerminoma
- ■
Yolk sac tumor
- ■
Struma ovarii
- ■
Malignant melanoma
- ■
Sertoli cell tumor
- ■
Steroid cell tumors
- ■
Epithelioid smooth muscle tumors
- ■
Solid pseudopapillary tumor
Metastatic Tumors
- ■
Clear cell carcinoma arising elsewhere in the female genital tract
- ■
Renal cell carcinoma
- ■
Clear cell intestinal carcinoma
- ■
Malignant melanoma
Tumor-Like Lesions
- ■
Arias-Stella reaction in endometriosis
- ■
Epithelial inclusion glands and cysts with hydropic change
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