Eosinophilic Angiocentric Fibrosis
Bruce M. Wenig, MD
Key Facts
Terminology
Rare, chronic, sclerosing, fibroinflammatory disorder of upper aerodigestive tract
Etiology/Pathogenesis
No known association with systemic or other localized disease(s)
Postulated to represent mucosal variant of granuloma faciale
Clinical Issues
Primarily involves nasal cavity
Surgery may be required in patients with airway obstruction
Microscopic Pathology
Early phase: Eosinophilic perivascular infiltrate in lamina propria with eosinophilic angiitis
Late phase: Dense fibrosis with layered onion-skin-type perivascular fibrosis (angiocentric fibrosis)
 A mixed inflammatory cell infiltrate, including numerous eosinophils, is present and may be associated with small vessel walls  suggesting a small vessel angiitis. |
 Prominent stromal fibrosis with layered “onion-skin-type” perivascular fibrosis  is a characteristic feature. Ischemic-type necrosis, granulomas, and multinucleated giant cells are absent. |
TERMINOLOGY
Abbreviations
Eosinophilic angiocentric fibrosis (EAF)
Definitions
Rare, chronic, sclerosing, fibroinflammatory disorder of upper aerodigestive tract
ETIOLOGY/PATHOGENESIS
Idiopathic
No known etiology; no known association with other (systemic or localized) diseases
Postulated to represent mucosal variant of granuloma faciale due to
Histologic similarities of early nasal mucosal lesions to granuloma faciale
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