Eccrine Hamartomas
Christine J. Ko, MD
Key Facts
Microscopic Pathology
Eccrine angiomatous hamartoma
Eccrine glands normal (occasionally enlarged) or increased in number
Endothelial cell-lined, thin-walled vascular spaces intimately admixed with eccrine glands
Differential diagnosis includes eccrine nevus
Coccygeal polypoid eccrine nevus
Polypoid shape
Increased number of eccrine glands
Differential diagnosis includes skin tag
Porokeratotic eccrine ostial and dermal duct nevus
Cornoid lamellae (tiers of parakeratosis over diminished granular layer) above acrosyringeal ducts &/or hair follicles
Differential diagnosis includes porokeratosis
Eccrine nevus
Increased number or size of eccrine glands
No increase in vessels; not polypoid
 This is a porokeratotic eccrine ostial and dermal duct nevus with light pink, hyperkeratotic streaks following Blaschko lines. There are focal spines. (Courtesy J. McNiff, MD and R. Antaya, MD.) |
 Biopsy of porokeratotic eccrine ostial and dermal duct nevus shows tiers of parakeratosis (cornoid lamellae)  overlying acrosyringeal ostia. The inset is another example. (Courtesy J. McNiff, MD.) |
TERMINOLOGY
Synonyms
Eccrine angiomatous hamartoma
Sweating angiomatous hamartoma
Sudoriparous angioma
Functioning sudoriparous angiomatous hamartoma
Porokeratotic eccrine ostial and dermal duct nevus
Porokeratotic eccrine duct and hair follicle nevus
Porokeratotic adnexal ostial nevus
Definitions
Lesions, often congenital, with prominent component of eccrine glands
CLINICAL ISSUES
Presentation
Eccrine angiomatous hamartoma
Congenital or develops in childhood; may present in adulthood
Occasionally familial
Symptoms/signs
May be asymptomatic
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