Basophilia



Basophilia


Kathryn Foucar, MD









Peripheral blood smear shows normal basophil. Note that the granules obscure the nucleus.






Peripheral blood smear shows neutrophil and degranulated basophil image.


TERMINOLOGY


Definitions



  • Absolute basophil count exceeding 0.2 × 109/L


  • Basophil recognized by its unique, dark, purple secondary granules



    • Granules contain heparin, histamine, eosinophil chemotactic factor, and slow-reacting substance of anaphylaxis


ETIOLOGY/PATHOGENESIS


Pathophysiology



  • Linked to interleukin (IL)-3, IL-5, and granulocyte-monocyte-colony stimulating factor (GM-CSF)


  • Basophils derived from common granulocytic progenitor cells


Multifactorial Causes



  • Causes of secondary basophilia generally linked to allergic/hypersensitivity disorders or chronic inflammatory conditions

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Jun 13, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Basophilia
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