Aspergillosis



Aspergillosis


Andrew C. Walls, BSc

Chad Jessup, MD, MS

Martin C. Mihm, Jr., MD










Classic cutaneous aspergillosis lesion demonstrates an evolving violaceous nodule with central ulceration image and eschar formation image.






H&E (left) and GMS (right) stains of cutaneous aspergillosis demonstrate numerous septated fungal hyphae image with dichotomous 45° angle branching image. (Courtesy L Thompson, MD.)


TERMINOLOGY


Definitions



  • Cutaneous fungal infection due to angioinvasive Aspergillus spp.


  • Primary cutaneous lesions arise from direct local inoculation/colonization



    • Host is most often immunocompromised or, rarely immunocmpetent


  • Secondary cutaneous lesions arise from hematogenous dissemination, usually of sinobronchopulmonary origin, in immunocompromised host


ETIOLOGY/PATHOGENESIS


Environmental Exposure



  • Ubiquitous soil and water-dwelling fungal organism


  • Contact made through direct inhalation of spores (conidia) or primary inoculation of skin


  • Hospital renovations or construction may increase ambient spore count

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Aspergillosis
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