Andrew C. Walls, BSc

Chad Jessup, MD, MS

Martin C. Mihm, Jr., MD

Classic cutaneous aspergillosis lesion demonstrates an evolving violaceous nodule with central ulceration image and eschar formation image.

H&E (left) and GMS (right) stains of cutaneous aspergillosis demonstrate numerous septated fungal hyphae image with dichotomous 45° angle branching image. (Courtesy L Thompson, MD.)



  • Cutaneous fungal infection due to angioinvasive Aspergillus spp.

  • Primary cutaneous lesions arise from direct local inoculation/colonization

    • Host is most often immunocompromised or, rarely immunocmpetent

  • Secondary cutaneous lesions arise from hematogenous dissemination, usually of sinobronchopulmonary origin, in immunocompromised host


Environmental Exposure

  • Ubiquitous soil and water-dwelling fungal organism

  • Contact made through direct inhalation of spores (conidia) or primary inoculation of skin

  • Hospital renovations or construction may increase ambient spore count

Infectious Agents

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Aspergillosis

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