Antibodies Discussed

Antibody Name/Symbol

Antibody Description

Clones/Alternative Names

Chapters

β-2-microglobulin

component of MHC class I molecules

B2-MICROGLB

Lymphoplasmacytic Lymphoma; Splenic B-cell Marginal Zone Lymphoma

κ light chain

kappa light chain

KAPPA

λ light chain

lambda light chain

LAMBDA

AE1

detects a variety of low to intermediate molecular weight cytokeratins

Hematopoiesis and Bone Marrow Histology

AE1/AE3

mixture of 2 anticytokeratin clones that detect a variety of both high and low molecular weight cytokeratins

Metastatic Carcinoma and Sarcoma

ALK

anaplastic lymphoma kinase-1

5A4, ALK1, ALKC

Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview of Lymphoid Neoplasms; Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms

ALK1

anaplastic lymphoma kinase-1

5A4, ALK, ALKC

Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Bone Marrow Examination and Techniques; Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes

Annexin-A1

mediator of anti-inflammatory response and upregulated in hairy cell leukemia

ANXA1, LPC1, lipocortin

Hairy Cell Leukemia; Pancytopenia

Bcl-2

B-cell CLL lymphoma 2; suppresses apoptosis in a variety of cell systems

ONCL2, BCL2/100/D5, 124, 124.3

Burkitt Leukemia/Lymphoma; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Hairy Cell Leukemia; Other B-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Plasma Cell Myeloma

Bcl-6

B-cell CLL lymphoma 6

LN22, GI191E/A8, N-3, PG-B6P, P1F6, 3FR-1

Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes; Lymphoid Aggregates in Bone Marrow; Other B-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Splenic B-cell Marginal Zone Lymphoma

BRCA1

breast and ovarian cancer susceptibility protein 1

MS110

Fanconi Anemia

CD1a

T-cell surface glycoprotein

JPM30, CD1A, O10, NA1/34

Langerhans Cell Histiocytosis in Bone Marrow; Lysosomal Storage Diseases with Predominantly Histiocytic Storage; Other T-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; T-cell Prolymphocytic Leukemia; T-lymphoblastic Leukemia/Lymphoma

CD2

T-cell surface antigen, LFA2

271, MT910, AB75, LFA-2

Acute Promyelocytic Leukemia with t(15;17) (q22;q21);PML-RARA and Variants; Acute Myeloid Leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1; Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; B Lymphoblastic Leukemia; Chronic Myelomonocytic Leukemia; Mast Cell Leukemia; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview of Myeloproliferative Neoplasms; Paroxysmal Nocturnal Hemoglobinuria; Post-Transplant Lymphoproliferative Disorders in Bone Marrow; Systemic Mastocytosis; T-cell Prolymphocytic Leukemia; T-lymphoblastic Leukemia/Lymphoma

CD3

Acquired Aplastic Anemia; Acute Undifferentiated Leukemia; Adult T-cell Leukemia; Aggressive NK-cell Leukemia; Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Bone Marrow Examination and Techniques; Chronic Lymphoproliferative Disorder of NK Cells; Hematopoiesis and Bone Marrow Histology; Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes; Human Immunodeficiency Virus; Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus); Lymphoid Aggregates in Bone Marrow; Lymphopenia, Constitutional and Acquired; Mixed Phenotype Acute Leukemia; Mycosis Fungoides/Sézary Syndrome; Other T-cell Non-Hodglin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Hemophagocytic Disorders in Bone Marrow; Overview and Classification of Mature T/NK-Cell Neoplasms; Post-Transplant Lymphoproliferative Disorders in Bone Marrow; Systemic Mastocytosis; T-cell Large Granular Lymphocytic Leukemia; T-cell Prolymphocytic Leukemia; T-lymphoblastic Leukemia/Lymphoma

CD4

T-cell surface glycoprotein L3T4

IF6, 1290, 4B12

Acute Monoblastic and Monocytic Leukemia; Acute Myeloid Leukemia with Maturation; Acute Myeloid Leukemia with t(9;11)(p22;q23); MLLT3-MLL; Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Blastic Plasmacytoid Dendritic Cell Neoplasm; Bone Marrow Examination and Techniques; Burkitt Leukemia/Lymphoma; Fungal Infections, Blood and Bone Marrow Features; Human Immunodeficiency Virus; Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus); Langerhans Cell Histiocytosis in Bone Marrow; Lymphopenia, Constitutional and Acquired; Mycosis Fungoides/Sézary Syndrome; Other T-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview of Acute Myeloid Leukemia; Post-Transplant Lymphoproliferative Disorders in Bone Marrow; T-cell Large Granular Lymphocytic Leukemia; T-cell Prolymphocytic Leukemia; Tlymphoblastic Leukemia/Lymphoma

CD5

T-cell surface glycoprotein Leu 1, T1

NCL-CD5, 4C7, 54/B4, 54/F6

Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; B-cell Prolymphocytic Leukemia; Bone Marrow Examination and Techniques; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Chronic Lymphoproliferative Disorder of NK Cells; Hairy Cell Leukemia; Hematogones in Bone Marrow; Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus); Lymphoid Aggregates in Bone Marrow; Mycosis Fungoides/Sézary Syndrome; Other B-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview and Classification of Myelodysplastic Syndromes; Overview of Lymphoid Neoplasms; Splenic B-cell Marginal Zone Lymphoma; T-cell Large Granular Lymphocytic Leukemia; T-cell Prolymphocytic Leukemia; T-lymphoblastic Leukemia/Lymphoma

CD7

T-cell antigen precursor Leu 9

272, CD7-272

Acute Monoblastic and Monocytic Leukemia; Acute Myelomonocytic Leukemia; Adult T-cell Leukemia; Acute Myeloid Leukemia with Maturation; Acute Myeloid Leukemia with Minimal Differentiation; Acute Myeloid Leukemia without Maturation; B Lymphoblastic Leukemia; Blastic Plasmacytoid Dendritic Cell Neoplasm; Mycosis Fungoides/Sézary Syndrome; Other T-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Mature T/NK-Cell Neoplasms; Post-Transplant Lymphoproliferative Disorders in Bone Marrow; Refractory Anemia With Excess Blasts; T-cell Large Granular Lymphocytic Leukemia; T-cell Prolymphocytic Leukemia; Tlymphoblastic Leukemia/Lymphoma

CD8

T-cell coreceptor antigen, Leu 2, Tcytotoxic cells

M7103, C8/144, C8/144B

Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Bone Marrow Examination and Techniques; Chronic Lymphoproliferative Disorder of NK Cells; Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus); Mycosis Fungoides/Sézary Syndrome; Other T-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Hemophagocytic Disorders in Bone Marrow; Overview and Classification of Mature T/NK-Cell Neoplasms; Post-Transplant Lymphoproliferative Disorders in Bone Marrow; Protocol for the Examination of Specimens from Patients with Non-Hodgkin Lymphoma/Lymphoid Neoplasms; T-cell Large Granular Lymphocytic Leukemia; T-cell Prolymphocytic Leukemia; T-lymphoblastic Leukemia/Lymphoma; WAS-related Disorders

CD10

neutral endopeptidase

CALLA, neprilysin, NEP

Acute Undifferentiated Leukemia; B Lymphoblastic Leukemia; Burkitt Leukemia/Lymphoma; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Chronic Myelogenous Leukemia, BCR-ABL1+; Hairy Cell Leukemia; Hematogones in Bone Marrow; Lymphoid Aggregates in Bone Marrow; Lymphoplasmacytic Lymphoma; Mixed Phenotype Acute Leukemia; Other B-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Other T-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Overview of Lymphoid Neoplasms; T-lymphoblastic Leukemia/Lymphoma

CD11c

integrin alpha X chain protein

LEU-M5

Acute Monoblastic and Monocytic Leukemia; Acute Myelomonocytic Leukemia; Acute Myeloid Leukemia with Maturation; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Hairy Cell Leukemia;

CD12

CDw12

Blastic Plasmacytoid Dendritic Cell Neoplasm

CD13

plays role in growth of DC/macrophage progenitors and precursors

Acute Megakaryoblastic Leukemia; Acute Monoblastic and Monocytic Leukemia; Acute Panmyelosis with Myelofibrosis; Acute Promyelocytic Leukemia with t(15;17) (q22;q21);PML-RARA and Variants; Acute Undifferentiated Leukemia; Acute Myeloid Leukemia with t(9;11)(p22;q23); MLLT3-MLL; B-Lymphoblastic Leukemia; Mast Cell Leukemia; Mixed Phenotype Acute Leukemia; Monocytosis; Overview and Classification of Myelodysplastic Syndromes; Refractory Anemia With Excess Blasts

CD14

coreceptor for lipopolysaccharide binding protein

FMC32

Acute Monoblastic and Monocytic Leukemia; Acute Myeloid Leukemia with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22); CBFB-MYH11; Acute Myeloid Leukemia with t(9;11)(p22;q23); MLLT3-MLL; Blastic Plasmacytoid Dendritic Cell Neoplasm; Mast Cell Leukemia; Monocytosis; Paroxysmal Nocturnal Hemoglobinuria

CD15

reacts with Reed-Sternberg cells of Hodgkin disease and with granulocytes

VIM-2,3C4, LEU-M1, TU9, VIMD5, MY1, CBD1, MMA, 3CD1, C3D1, Lewis x, SSEA-1

Acute Monoblastic and Monocytic Leukemia; Acute Myelomonocytic Leukemia; Acute Promyelocytic Leukemia with t(15;17)(q22;q21);PML-RARA and Variants; Acute Myeloid Leukemia with Maturation; Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes; Mast Cell Leukemia; Other T-NHL Involving Blood and Bone Marrow; Overview and Classification of Myelodysplastic Syndromes; Post-Transplant Lymphoproliferative Disorders in Bone Marrow

CD16

Fc receptor of IgG

Chronic Lymphoproliferative Disorder of NK Cells; Monocytosis; Other T-NHL Involving Blood and Bone Marrow; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview and Classification of Myelodysplastic Syndromes; Paroxysmal Nocturnal Hemoglobinuria; T-cell Large Granular Lymphocytic Leukemia

CD19

B-cell antigen

Acute Undifferentiated Leukemia; Acute Myeloid Leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1; B Lymphoblastic Leukemia; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Chronic Myelogenous Leukemia, BCR-ABL-1+; Hematogones in Bone Marrow; Lymphoid Aggregates in Bone Marrow; Mixed Phenotype Acute Leukemia; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Plasma Cell Myeloma; Splenic B-cell Marginal Zone Lymphoma

CD20

membrane spanning 4 domains of Blymphocytes

FB1, B1, L26, MS4A1

Acquired Aplastic Anemia; B Lymphoblastic Leukemia; Blastic Plasmacytoid Dendritic Cell Neoplasm; Burkitt Leukemia/Lymphoma; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Granulomas in Bone Marrow; Hairy Cell Leukemia; Hematogones in Bone Marrow; Hematopoiesis and Bone Marrow Histology; Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes; Human Immunodeficiency Virus; Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus); Lymphoid Aggregates in Bone Marrow; Lymphoplasmacytic Lymphoma; Other B-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Overview of Lymphoid Neoplasms; Pancytopenia; Plasma Cell Myeloma; Splenic B-cell Leukemia; Hairy Cell Leukemia Variant; Splenic B-cell Marginal Zone Lymphoma; Systemic Mastocytosis

CD21

CR2, complement component receptor 2, Epstein-Barr virus receptor

IF8

Langerhans Cell Histiocytosis in Bone Marrow

CD22

B-cell receptor

FPC1, LEU 14

Bone Marrow Examination and Techniques; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Hairy Cell Leukemia; Lymphoplasmacytic Lymphoma

CD23

Fc ε RII, low-affinity IgE receptor, IGEBF

1B12, MHM6BU38

Burkitt Leukemia/Lymphoma; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Hairy Cell Leukemia; Lymphoplasmacytic Lymphoma; Other B-cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow; Overview of Lymphoid Neoplasms; Splenic B-cell Marginal Zone Lymphoma

CD24

sialic acid epitope of B lymphocytes

BA-1

Paroxysmal Nocturnal Hemoglobinuria

CD25

If-2 receptor alpha

2A3, 4C9

Acute Myeloid Leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1; B Lymphoblastic Leukemia; Basophilia; Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma; Hairy Cell Leukemia; Mast Cell Leukemia; Overview and Classification of Hemophagocytic Disorders in Bone Marrow; Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview of Myeloproliferative Neoplasms; Splenic B-cell Leukemia; Hairy Cell Leukemia Variant; Systemic Mastocytosis; T-cell Large Granular Lymphocytic Leukemia; T-cell Prolymphocytic Leukemia

CD27

TNF receptor

Lymphoplasmacytic Lymphoma

CD30

tumor necrosis factor SF8

BER-H2, KI-1, TNFRSF8

Anaplastic Large Cell Lymphoma in Blood and Bone Marrow; Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes; Lymphoid Aggregates in Bone Marrow; Mast Cell Leukemia; Overview and Classification of Mature T/NK-Cell Neoplasms; Overview of Lymphoid Neoplasms; Post-Transplant Lymphoproliferative Disorders in Bone Marrow

CD31

platelet endothelial cell adhesion molecule

JC/70, JC/70A, PECAM-1

Acute Megakaryoblastic Leukemia; Acute Myeloid Leukemia with Minimal Differentiation; Chronic Myelogenous Leukemia, BCR-ABL1+; MDS with Isolated del (5q); Myeloid Proliferations Related to Down Syndrome; Myeloproliferative Neoplasm, Unclassifiable; Overview and Classification of Myeloid Neoplasms; Overview of Megakaryocytic Disorders; Pregnancy-associated Hematologic Disorders

CD33

SIGLEC lectin 3

PWS44

Acute Megakaryoblastic Leukemia; Acute Monoblastic and Monocytic Leukemia; Acute Undifferentiated Leukemia; Acute Myeloid Leukemia with inv(16)(p13.1;q22) or t(16;16) (p13.1;q22); CBFB-MYH11; Acute Myeloid Leukemia with Maturation; Acute Myeloid Leukemia with Minimal Differentiation; Acute Myeloid Leukemia with t(8;21)(q22;q22) RUNX1-RUNX1T1; Acute Myeloid Leukemia with t(9;11)(p22;q23); MLLT3-MLL; B Lymphoblastic Leukemia; Blastic Plasmacytoid Dendritic Cell Neoplasm; Bone Marrow Examination and Techniques; Mast Cell Leukemia; Mixed Phenotype Acute Leukemia; Overview and Classification of Myelodysplastic Syndromes; Overview of Acute Myeloid Leukemia; Plasma Cell Myeloma; Refractory Anemia With Excess Blasts

CD34

hematopoietic progenitor cell antigen

MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, NU-4A1, TUK4, clone 581, BI-3c5