Antibodies Discussed

Antibody Name/Symbol Antibody Description

Clones/Alternative Names

Chapters

α-fetoprotein

alpha 1 fetoprotein

AFP, Z5A06, clone C3

Atypical Teratoid/Rhabdoid Tumor; Germinoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Other Germ Cell Tumors; Teratomas

α-subunit

glycoprotein hormone alpha subunit

alpha subunit, α-SU

Gonadotroph Adenoma; Null Cell Adenoma; Pituitary Adenoma; Thyrotroph Adenoma

α-synuclein

Non-Aβ component (NAC) of Alzheimer disease amyloid, NACP; neuronal protein

Ganglion Cell Tumors

β-A4-amyloid

found in many tissues and organs, including the brain and spinal cord; may be involved in cell attachment

6F/3D, 4G8, amyloid precursor protein (APP), amyloid beta precursor protein (ABPP), Alzheimer disease amyloid protein, cerebral vascular amyloid peptide (CVAP)

Amyloid (Congophilic) Angiopathy

β-amyloid

extracellular filamentous protein deposit found in the brain

Miscellaneous Parasitic Infections; Primary Angiitis of the Central Nervous System

β-catenin

beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway

B-catenin, CLONE 14, E-5, RB-9035Po, 17C2, 5H10

Adamantinomatous Craniopharyngioma; Anaplastic Ependymoma; CNS Primitive Neuroectodermal Tumors; Medulloblastoma; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

β-endorphin

endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous systems

B-endorphin

Corticotroph Adenoma; Pituitary Adenoma

β-tubulin

beta tubulin

B-tubulin, TUJ1

Tuberous Sclerosis Complex

ACTH

adrenocorticotropic hormone

Corticotroph Adenoma; Adamantinomatous Craniopharyngioma; Lymphocytic Hypophysitis; Pituitary Adenoma; Pituitary Blastoma; Pituitary Carcinoma; Pituitary Hyperplasia; Plurihormonal Adenoma; Secondary Neoplasms of the Pituitary and Sellar Region; Spindle Cell Oncocytoma

Actin-sm

actin, smooth muscle

SMA, ASM-1, CGA7, 1A4, HUC1-1

Atypical Teratoid/Rhabdoid Tumor; Smooth Muscle Neoplasms

Adenovirus

AdV

Other Viral Infections

AE1/AE3

mixture of 2 anticytokeratin clones that detect a variety of both high and low molecular weight cytokeratins

Atypical Teratoid/Rhabdoid Tumor; Germinoma; Meningioma; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Other Germ Cell Tumors; Paraganglioma of the Filum Terminale; Teratomas

AFP

alpha 1 fetoprotein

Z5A06, clone C3, α-fetoprotein

Germinoma

AID

activation-induced cytidine deaminase; an enzyme essential for somatic hypermutation

Anaplastic Ependymoma; Anaplastic Oligodendroglioma; Arteriovenous Malformation; Desmoplastic Infantile Ganglioglioma; Ependymoma; Germinoma; Glioblastoma; Pilocytic Astrocytoma; Pituitary Adenoma; Pleomorphic Xanthoastrocytoma; Primary Central Nervous System Lymphoma; Rathke Cleft Cyst

ALK

anaplastic lymphoma kinase 1

ALK1, 5A4, ALKC

Inflammatory Pseudotumors

Alpha subunit

glycoprotein hormone alpha subunit

alpha subunit, α-SU

Gonadotroph Adenoma; Null Cell Adenoma; Pituitary Blastoma; Thyrotroph Adenoma

Annexin-A1

regulates phospholipase A2 activity with potential anti-inflammatory activity

lipocortin I

Pituicytoma; Pituitary Blastoma; Spindle Cell Oncocytoma

Anti-Hu

antibody associated with paraneoplastic syndromes; polyclonal IgG that binds to neurons and other tumor cells that express Hu antigen

Rasmussen Encephalitis

Anti-mitochondrial antibody

associated with autoimmune diseases such as primary biliary cirrhosis

Spindle Cell Oncocytoma

APC

adenomatous polyposis coliprotein

Turcot Syndrome

Bc1-2

B-cell lymphoma 2; suppresses apoptosis in a variety of cell systems

ONCL2, BCL2/100/D5, 124, 124.3

Intravascular Lymphomatosis; Primary Central Nervous System Lymphoma; Solitary Fibrous Tumor; Solitary Fibrous Tumor, Hemangiopericytoma Type; Spindle Cell Oncocytoma

Bc1-6

B-cell CLL/lymphoma 6

LN22, GI191E/A8, N-3, PG-B6P, P1F6, 3FR-1

Intravascular Lymphomatosis

BER-EP4

epithelial cell adhesion molecule

AUA1, VU-1D9, EPCAM, C10, HEA125

Choroid Plexus Carcinoma; Endodermal Cyst; Metastatic Neoplasms, Intracranial and Intraspinal Meninges

Brachyury

crucial regulator of notochordal development and biomarker for chordomas

Osteocartilaginous Neoplasms

C-Kit

C-kit; tyrosine-protein kinase activity

CD117, C-19 (C-KIT), 104D2, 2E4, CKIT, A4502, H300, CMA-767

Atypical Teratoid/Rhabdoid Tumor; Germinoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Other Germ Cell Tumors

C-myc

myelocytomatosis viral oncogene

C-MYC, 9E10, 9E11, 1-262

Gliosarcoma

CAM 5.2

cytokeratin 8/18 (CAM5.2)

5D3, Zym5.2, 5D3, KER 10.11, NCL-5D3

Pituitary Blastoma

Carcinoembryonic antigen

CEA-M, mCEA, CEA-B18, CEA-D14, CEAGOLD 1, T84.6, CEA-GOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEAGOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEA-M, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEA-M431_31, CEJO65

Meningioma

Caspase-1

promotes maturation of IL-1b and IL-18 by proteolytic cleavage; implicated in inflammation, septic shock, wound healing, and growth of certain leukemias.

HIV Encephalitis

CD1a

T-cell surface glycoprotein

JPM30, CD1A, O10, NA1/34

Erdheim-Chester Disease; Langerhans Cell Histiocytosis; Rosai-Dorfman Disease

CD2

T-cell surface antigen, LFA2

271, MT910, AB75, LFA-2

Primary Central Nervous System Lymphoma

CD3

T-cell receptor

F7238, A0452, CD3-P, CD3-M, SP7, PS1

Herpes Simplex Encephalitis; Lymphocytic Hypophysitis; Other Viral Infections; Primary Angiitis of the Central Nervous System; Primary Central Nervous System Lymphoma; Rasmussen Encephalitis; Sarcoidosis; Secondary Neoplasms of the Pituitary and Sellar Region

CD4

T-cell surface glycoprotein, L3T4

IF6, 1290, 4B12, 1F6, CD04

HIV Encephalitis

CD5

T-cell surface glycoprotein Leu1, T1

NCL-CD5, 4C7, 54/B4, 54/F6

Intravascular Lymphomatosis

CD10

neutral endopeptidase

NCL-270, CALLA, neprilysin, NEP

Hemangioblastoma; Intravascular Lymphomatosis; Lymphomatoid Granulomatosis; Metastatic Neoplasms, Intracranial and Intraspinal Meninges

CD20

membrane spanning 4 domains of B-lymphocytes

FB1, B1, L26, MS4A1

Herpes Simplex Encephalitis; Intravascular Lymphomatosis; Lymphocytic Hypophysitis; Lymphomatoid Granulomatosis; Lymphomatosis Cerebri; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Primary Angiitis of the Central Nervous System; Primary Central Nervous System Lymphoma; Sarcoidosis; Secondary Neoplasms of the Pituitary and Sellar Region

CD22

BER-H2, KI-1, TNFRSF8

FPC1, LEU-14

Intravascular Lymphomatosis

CD30

tumor necrosis factor SF8

BER-H2, KI-1, TNFRSF8

Germinoma; Other Germ Cell Tumors; Primary Central Nervous System Lymphoma

CD31

platelet endothelial cell adhesion molecule

JC/70, JC/70A, PECAM-1

Hemangioblastoma; Intravascular Lymphomatosis

CD34

hematopoietic progenitor cell antigen

MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, NU-4A1, TUK4, clone 581, BI-3c5

Capillary Hemangioma; Chordoid Glioma of the 3rd Ventricle; Extraneural Neurofibroma Variants; Ganglion Cell Tumors; Hemangioblastoma; Meningioma; Pituitary Carcinoma; Smooth Muscle Neoplasms; Soft Tissue Perineurioma; Solitary Fibrous Tumor; Solitary Fibrous Tumor, Hemangiopericytoma Type; Spindle Cell Oncocytoma

CD43

Major sialoglycoprotein on surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes

LEU-22, DF-T1, L60, MT1, sialophorin, leukosialin, SPN

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Primary Central Nervous System Lymphoma; Subdural Hematoma

CD45

leukocyte common antigen

LCA, PD7/26, 1.22/4.14, T29/33, RP2/18, PD7, 2D1, 2B11+PD7/26

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Primary Central Nervous System Lymphoma; Subdural Hematoma; Amebiasis; Ganglion Cell Tumors; Gliomatosis Cerebri; Intravascular Lymphomatosis;

CD56

NCAM (neutral cellular adhesion molecule)

MAB735, ERIC-1, 25-KD11, 123C3, 24-MB2, BC56C04, 1B6, 14-MAB735, NCC-LU-243, MOC-1, NCAM

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

CD57

β-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)

LEU-7, NK1, HNK-1, TB01, B3GAT1

Cellular Schwannoma; Conventional Schwannoma; Malignant Peripheral Nerve Sheath Tumor; Solitary Fibrous Tumor

CD64

Fc receptor for IgG antibodies, high affinity

HAM56

Granular Cell Astrocytoma of the Cerebrum

CD68

cytoplasmic granule protein of monocytes, macrophages

PG-M1, KP-1, LN5

Conventional Schwannoma; Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Erdheim-Chester Disease; Ganglion Cell Tumors; Glioblastoma; Granular Cell Astrocytoma of the Cerebrum; Herpes Simplex Encephalitis; Infarct; Inflammatory Pseudotumors; Lymphocytic Hypophysitis; Lymphomatosis Cerebri; Other Viral Infections; Paraneoplastic Disease; Pituicytoma; Primary Central Nervous System Lymphoma; Rasmussen Encephalitis; Rosai-Dorfman Disease; Sarcoidosis; Subdural Hematoma

CD79-a

immunoglobulin-associated alpha, MB1

MB-1, 11D10, 11E3, CD79A, HM47/A9, HM57, JCB117, CD79a, CD79-α

Intravascular Lymphomatosis; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Primary Central Nervous System Lymphoma

CD99

cell surface glycoprotein for migration, T cell adhesion

CD99-MEMB, MIC2, 12E7, HBA71, O13, P30/32MIC2, M3601

CNS Primitive Neuroectodermal Tumors; Osteocartilaginous Neoplasms; Peripheral Primitive Neuroectodermal Tumor (Ewing Sarcoma); Solitary Fibrous Tumor

CD117

C-kit, tyrosine-protein kinase activity

C-19 (C-KIT), 104D2, 2E4, C-KIT, A4502, H300, CMA-767

Atypical Teratoid/Rhabdoid Tumor; Germinoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Other Germ Cell Tumors; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Teratomas

CD163

macrophage hemoglobin scavenging system

10D6

Glioblastoma; Granular Cell Astrocytoma of the Cerebrum; HIV Encephalitis; Primary Central Nervous System Lymphoma

CDX-2

caudal type homeobox transcription factor 2

AMT28, 7C7/D4, CDX-2-88

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

CEA-M

carcinoembryonic antigen, monoclonal

CEA-B18, CEA-D14, CEA-GOLD 1, T84.6, CEAGOLD 2, CEA 11, CEA-GOLD 3, CEA 27, CEAGOLD 4, CEA 41, CEA-GOLD 5, T84.1, CEAM, A5B7, CEJ065, IL-7, T84.66, TF3H8-1, 0062, D14, alpha-7, PARLAM 1, ZC23, CEM010, A115, COL-1, AF4, 12.140.10, 11-7, M773, CEAM431_31, CEJO65, mCEA

Meningioma

CEA-P

carcinoembryonic antigen, polyclonal

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

Chromogranin-A

pituitary secretory protein 1

PHE-5, PHE5, E001, DAK-A3

Central Neurocytoma; CNS Primitive Neuroectodermal Tumors; Desmoplastic Infantile Ganglioglioma; Extraventricular Neurocytoma; Ganglion Cell Tumors; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Null Cell Adenoma; Paraganglioma of the Filum Terminale; Pituitary Adenoma; Pituitary Blastoma

CK-PAN

cytokeratin-pan (AE1/AE3/LP34); cocktail of high and low molecular weight cytokeratins

keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin

Malignant Peripheral Nerve Sheath Tumor; Meningioma; Papillary Craniopharyngioma; Peripheral Primitive Neuroectodermal Tumor (Ewing Sarcoma); Pituitary Blastoma

CK5/6

cytokeratin 5/6, high molecular weight cytokeratins

D5/16 B4

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

CK7

cytokeratin 7, low molecular weight cytokeratin

K72.7, KS7.18, OVTL 12/30, LDS-68, CK 07

Adamantinomatous Craniopharyngioma; Adipositic Neoplasms; Choroid Plexus Papilloma and Atypical Papilloma; Colloid Cyst; Meningioma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Teratomas

CK8

cytokeratin 8

K8.8, 4.1.18, TS1, C-51, M20, CK 08, 35BH11, MA-902

Osteocartilaginous Neoplasms; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma)

CK8/18/CAM5.2

Cytokeratin 8/18; simple epithelial-type cytokeratins

5D3, Zym5.2, CAM 5.2, KER 10.11, NCL-5D3, cytokeratin LMW

Corticotroph Adenoma; Adamantinomatous Craniopharyngioma; Endodermal Cyst; Malignant Peripheral Nerve Sheath Tumor; Meningioma; Papillary Tumor of the Pineal Region; Paraganglioma of the Filum Terminale; Pituitary Blastoma; Somatotroph Adenoma;

CK18

cytokeratin 18

M9, DC-10, CY-90, KS18.04

Other Germ Cell Tumors; Osteocartilaginous Neoplasms; Papillary Tumor of the Pineal Region; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma)

CK19

cytokeratin 19, low molecular weight cytokeratin

BA17, RCK108, LP2K, B170, A53-BA2, KS19.1, 170.2.14

Osteocartilaginous Neoplasms

CK20

cytokeratin 20, low molecular weight cytokeratin

KS20.8

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Teratomas

CLA

cutaneous lymphocyte antigen

Inflammatory Pseudotumors

Claudin-1

senescence-associated epithelial membrane protein

JAD.8

Soft Tissue Perineurioma

CMV

Cytomegalovirus

Other Viral Infections

Collagen IV

major constituent of the basement membranes along with laminins, proteoglycans, and enactins

CIV22, COL4A [1-5], collagen α-1(IV) chain

Cellular Schwannoma; Conventional Schwannoma; Ependymoma; Extraneural Neurofibroma Variants; Ganglion Cell Tumors; Malignant Peripheral Nerve Sheath Tumor; Melanotic Schwannoma; Meningioma; Paraganglioma of the Filum Terminale; Pituitary Blastoma; Plexiform Neurofibroma; Primary Melanocytic Neoplasms; Schwannomatosis; Soft Tissue Perineurioma; Solitary Fibrous Tumor

Cytokeratin

Corticotroph Adenoma; Choroid Plexus Papilloma and Atypical Papilloma; CNS Primitive Neuroectodermal Tumors; Colloid Cyst; Ependymal Cyst; Germinoma; Lymphocytic Hypophysitis; Malignant Peripheral Nerve Sheath Tumor; Meningioma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Osteocartilaginous Neoplasms; Primary Melanocytic Neoplasms; Smooth Muscle Neoplasms; Spindle Cell Oncocytoma

D2-40

reacts with an O-linked sialoglycoprotein found on lymphatic endothelium

podoplanin, M2A

Osteocartilaginous Neoplasms

Desmin

class III intermediate filaments found in muscle cells

M760, DE-R-11, D33, DE5, DE-U-10, ZC18

Anaplastic Ependymoma; Atypical Teratoid/Rhabdoid Tumor; Cerebellar Liponeurocytoma; Conventional Schwannoma; Gliosarcoma; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Pineal Anlage Tumor; Plexiform Schwannoma; Smooth Muscle Neoplasms; Soft Tissue Perineurioma; Solitary Fibrous Tumor; Spindle Cell Oncocytoma; Teratomas

DPC4

mothers against DPP homolog 4

MADR1 JV4-1, DPC4_SMAD4, SMAD4, B-8

Metastatic Neoplasms, Intracranial and Intraspinal Meninges

Eastern equine encephalitis

arbovirus present in North, Central, and South America and the Caribbean; transmission by mosquito bite

Other Viral Infections

EBER

Epstein-Barr virus encoded RNA

Primary Angiitis of the Central Nervous System

EGFR

v-erb b1 erythroblastic leukemia viral gene, epidermal growth factor receptor

2-18C9, EGFR1, EGFR PHRMDX, NCL-R1, H11, CERBB-1, E30, EGFR.113, 31G73C6, 2-18C9

Central Neurocytoma; Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Glioblastoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges

EGFRVIII

Deletion-mutant EGFR identified in a subset of gliomas and non-small cell lung carcinomas

Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination)

EMA

epithelial membrane antigen

GP1.4, 214D4, MC5, E29, MUC1, LICRLON-M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8, MUC1, MAM6, CA15.3, MUC01

Anaplastic Ependymoma; Anaplastic Oligodendroglioma; Angiocentric Glioma; Astroblastoma; Atypical Teratoid/Rhabdoid Tumor; Calcifying Pseudoneoplasm of the Neuraxis; Chordoid Glioma of the 3rd Ventricle; Choroid Plexus Carcinoma; Colloid Cyst; Conventional Schwannoma; Endodermal Cyst; Ependymal Cyst; Ependymoma; Extraneural Neurofibroma Variants; Germinoma; Glioblastoma; Granular Cell Tumor of Infundibulum; Hemangioblastoma; Intraneural Perineurioma; Localized Intraneural Neurofibroma; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Medulloblastoma; Meningioangiomatosis; Meningioma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Myxopapillary Ependymoma; Osteocartilaginous Neoplasms; Papillary Tumor of the Pineal Region; Pituicytoma; Pituitary Blastoma; Plexiform Schwannoma; Primary Melanocytic Neoplasms; Secondary Neoplasms of the Pituitary and Sellar Region; Smooth Muscle Neoplasms; Soft Tissue Perineurioma; Solitary Fibrous Tumor; Solitary Fibrous Tumor, Hemangiopericytoma Type; Spindle Cell Oncocytoma

EMA/MUC1

epithelial membrane antigen

EMA, GP1.4, 214D4, MC5, E29, MUC1, LICRLON- M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8, MAM6, CA15.3, MUC01

Atypical Teratoid/Rhabdoid Tumor; Choroid Plexus Papilloma and Atypical Papilloma; Meningioma

Endoglin

type I membrane glycoprotein expressed in endothelial cells

CD105

Pituitary Carcinoma

EpCAM/BER-EP4/CD326

epithelial cell adhesion molecule

AUA1, VU-1D9, EPCAM, C10, HEA125, BEREP4

Endodermal Cyst; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

Epidermal growth factor

regulation of cell growth, proliferation, and differentiation through binding of epidermal growth factor receptor (EGFR)

EGF, KME-10

Pituitary Adenoma

Epithelial membrane antigen

EMA

Ependymoma; Meningioangiomatosis; Papillary Craniopharyngioma; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Rosai-Dorfman Disease

Erythropoietin

EPO

Subdural Hematoma

FLI-1

Friend leukemia virus integration 1

EWSR2, GI146-222, SC356, FLK-1, FLT-1

Peripheral Primitive Neuroectodermal Tumor (Ewing Sarcoma)

FSH

follicle stimulating hormone

Gonadotroph Adenoma; Pituitary Adenoma; Pituitary Hyperplasia; Plurihormonal Adenoma

FXIIIA

factor XIIIA (fibrin stabilizing factor)

factor XIIIa

Solitary Fibrous Tumor

GAB1

growth factor receptor bound protein 2-associated protein 1 antibody

Grb2-associated binder-1

Medulloblastoma; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

GAD-67

glutamic acid decarboxylase 67

Hypothalamic Hamartoma

Galectin-3

NCL-GAL3, B2C10, 9C4

Granular Cell Tumor of Infundibulum; Pituicytoma; Pituitary Blastoma; Spindle Cell Oncocytoma

GATA3

endothelial transcription factor 3

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

GFAP

intermediate filament expressed by numerous cells of the CNS

6F2, M761, GA-51, GFP-8A

Abscess and Cerebritis; Amebiasis; Anaplastic Ependymoma; Anaplastic Oligodendroglioma; Angiocentric Glioma; Astroblastoma; Atypical Teratoid/Rhabdoid Tumor; Cellular Schwannoma; Central Neurocytoma; Cerebellar Liponeurocytoma; Chordoid Glioma of the 3rd Ventricle; Choroid Plexus Papilloma and Atypical Papilloma; CNS Primitive Neuroectodermal Tumors; Conventional Schwannoma; Cortical Dysplasia; Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Desmoplastic Infantile Ganglioglioma; Diffuse Astrocytoma; Dysembryoplastic Neuroepithelial Tumor; Embryonal Tumor with Abundant Neuropil and True Rosettes; Ependymoma; Extraventricular Neurocytoma; Ganglion Cell Tumors; Glioblastoma; Gliomatosis Cerebri; Gliosarcoma; Granular Cell Astrocytoma of the Cerebrum; Granular Cell Tumor of Infundibulum; Hemangioblastoma; Malignant Glioneuronal Tumors; Medulloblastoma; Melanotic Schwannoma; Meningeal Glioma and Gliomatosis; Meningioma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Mixed Oligoastrocytoma; Myxopapillary Ependymoma; Papillary Glioneuronal Tumor; Paraganglioma of the Filum Terminale; Pilocytic Astrocytoma; Pilomyxoid Astrocytoma; Pineal Cyst; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Pituicytoma; Pituitary Adenoma; Pleomorphic Xanthoastrocytoma; Rasmussen Encephalitis; Rosette-Forming Glioneuronal Tumor of the 4th Ventricle; Spindle Cell Oncocytoma; Subependymal Giant Cell Astrocytoma; Subependymoma; Teratomas; Tuberous Sclerosis Complex

GH

growth hormone

HGH, hGH

Adamantinomatous Craniopharyngioma; Pituitary Adenoma; Pituitary Blastoma; Pituitary Carcinoma; Pituitary Hyperplasia; Plurihormonal Adenoma; Thyrotroph Adenoma; Somatotroph Adenoma

Glial fibrillary acidic protein

intermediate filament expressed by numerous cells of the CNS

GFAP, 6F2, M761, GA-51, GFP-8A

Meningeal Glioma and Gliomatosis; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Tuberous Sclerosis Complex

GLUT1

glucose transporter 1

Intraneural Perineurioma; Soft Tissue Perineurioma

Glycophorin-A

CD235a, JC159

Subdural Hematoma

Growth hormone

GH, hGH, HGH

Pituitary Adenoma; Pituitary Hyperplasia; Prolactinoma; Somatotroph Adenoma

H-caldesmon

High molecular weight caldesmon, H-CD

Smooth Muscle Neoplasms

HAM56

Fc receptor for IgG antibodies, high affinity

CD64

Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Glioblastoma; Granular Cell Astrocytoma of the Cerebrum

HCG

human chorionic gonadotropin

Germinoma; Other Germ Cell Tumors

HCG-β

human chorionic gonadotropin beta subunit

HCG-beta

Teratomas

HER2

v-erb-b2 erythroblastic leukemia viral gene protein, human epidermal growth factor receptor 2

c-erb-B2, HER2/neu, NEU, HER-2, NCL-CBE1, 10A7, 9G6.10, SP3, 4B5, epidermal growth factor receptor 2, P185, 9G6.20, A0485, C-ERBB-2, CB11, ERBB-2, 3B5, TAB250, HERCEPTEST, E2-4001, HER-2_NEU

Pituitary Carcinoma

Herpes simplex virus 1

HSV1

Herpes Simplex Encephalitis

HIV-gp120

HIV glycoprotein 120

HIV Encephalitis

HLA-DR

human leukocyte antigen DR

DK22, LN3, TAL.1B5, LK8D3

Rasmussen Encephalitis

HMB-45

antigen present in melanocytic tumors such as melanomas

LB39 AA, CMM1, CMM, DNS, FAMMM, Mart-1, Melan-A, MLM, tyrosinase

Melanotic Schwannoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Papillary Tumor of the Pineal Region; Primary Melanocytic Neoplasms; Solitary Fibrous Tumor

HSV1

herpes simplex virus 1

Herpes Simplex Encephalitis

IDH-1

mutant-specific antibodies that help distinguish tumor from reactive processes

isocitrate dehydrogenase 1

Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Cortical Dysplasia; Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Diffuse Astrocytoma; Glioblastoma; Oligodendroglioma; Pilocytic Astrocytoma

IGF-1

insulin growth factor-like 1

I-5C9

Somatotroph Adenoma

IgG

immunoglobulin G

IGG

Cysticercosis; Miscellaneous Parasitic Infections; Rasmussen Encephalitis

IgM

immunoglobulin M

IGM

Other Viral Infections

IL-1

involved in the inflammatory response, being identified as endogenous pyrogens

HIV Encephalitis

IL-1-β

involved in the inflammatory response, being identified as endogenous pyrogens

HIV Encephalitis

immunoglobulin A

IgA, IGA

Primary Central Nervous System Lymphoma

Inducible nitric oxide synthase

iNOs, INOS

HIV Encephalitis

Inhibin

produced by ovarian granulosa cells; inhibits production or secretion of pituitary gonadotropins, a sensitive marker for majority of sex cord-stromal tumors

Hemangioblastoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

INI1

member of SWI/SNF chromatin remodeling complex

BAF47/SNF5, SNF5

Anaplastic Ependymoma; Atypical Teratoid/Rhabdoid Tumor; Choroid Plexus Carcinoma; CNS Primitive Neuroectodermal Tumors; Glioblastoma; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Pineal Anlage Tumor; Schwannomatosis

iNOS

inducible nitric oxide synthase antibody; produces nitric oxide (NO); 1 of several family members of nitric oxide synthases (NOS); induced by interferon gamma and lipopolysaccharides in the kidney and cardiovascular system

INOS

HIV Encephalitis

IRF-4

interferon regulatory factor 4

MUM1P, clone MUM1, MUM1-IRF.4, MUM1, M17

Primary Central Nervous System Lymphoma

JC virus

type of human polyomavirus genetically similar to BK virus and SV-40

John Cunningham virus

Progressive Multifocal Leukoencephalopathy

Ki-67

marker of cell proliferation

MMI, KI88, IVAK-2, MIB1

Abscess and Cerebritis; Corticotroph Adenoma; Adamantinomatous Craniopharyngioma; Anaplastic Astrocytoma; Anaplastic Ependymoma; Anaplastic Oligodendroglioma; Atypical Teratoid/Rhabdoid Tumor; Capillary Hemangioma; Cellular Schwannoma; Central Neurocytoma; Choroid Plexus Carcinoma; Choroid Plexus Papilloma and Atypical Papilloma; CNS Primitive Neuroectodermal Tumors; Cortical Dysplasia; Desmoplastic Infantile Ganglioglioma; Diffuse Astrocytoma; Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease); Endodermal Cyst; Ependymoma; Extraneural Neurofibroma Variants; Ganglion Cell Tumors; Germinoma; Glioblastoma; Gliomatosis Cerebri; Gliosarcoma; Hemangioblastoma; Hypothalamic Hamartoma; Infarct; Intravascular Lymphomatosis; Gonadotroph Adenoma; Granular Cell Astrocytoma of the Cerebrum; Lymphomatosis Cerebri; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Medulloblastoma; Melanotic Schwannoma; Meningioangiomatosis; Meningioma; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Myxopapillary Ependymoma; Null Cell Adenoma; Oligodendroglioma; Papillary Craniopharyngioma; Papillary Tumor of the Pineal Region; Pilocytic Astrocytoma; Pineal Anlage Tumor; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Pituicytoma; Pituitary Adenoma; Pituitary Blastoma; Pituitary Carcinoma; Pituitary Hyperplasia; Plurihormonal Adenoma; Primary Angiitis of the Central Nervous System; Primary Melanocytic Neoplasms; Progressive Multifocal Leukoencephalopathy; Prolactinoma; Rosette-Forming Glioneuronal Tumor of the 4th Ventricle; Solitary Fibrous Tumor; Solitary Fibrous Tumor, Hemangiopericytoma Type; Somatotroph Adenoma; Spindle Cell Oncocytoma; Subdural Hematoma; Subependymal Giant Cell Astrocytoma; Subependymoma; Thyrotroph Adenoma

Laminin

major protein in basal lamina

LAMININ-4C7, 4C12.8, LAM-89

Ganglion Cell Tumors; Melanotic Schwannoma

Langerin

CD207 molecule

CD207

Langerhans Cell Histiocytosis; Lymphocytic Hypophysitis

LCA

leukocyte common antigen

PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26

Intravascular Lymphomatosis; Secondary Neoplasms of the Pituitary and Sellar Region

Leukocyte common antigen

LCA, PD7/26, 1.22/4.14, T29/33, CD45RB, RP2/18, CD45, PD7, 2D1, 2B11+PD7/26

Primary Central Nervous System Lymphoma

LH

Luteinizing hormone

beta-LH

Gonadotroph Adenoma; Pituitary Adenoma;

Lysozyme

1,4-beta N-acetylmuramidase C

Lyz, Lzm, Ec3.2.1.17

Primary Central Nervous System Lymphoma

Mammaglobin

breast tissue-specific glycoprotein

304-1A5

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Secondary Neoplasms of the Pituitary and Sellar Region

MAP2

microtubule associated protein 2

clone C, AP-20

Cerebellar Liponeurocytoma; Rosette-Forming Glioneuronal Tumor of the 4th Ventricle

MART-1

mart-1 clone of Melan-A

Primary Melanocytic Neoplasms

MBP

major basic protein

Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination)

Melan-A

melanoma antigen recognized by T cells 1 (MART-1); protein found on melanocytes; melanocyte differentiation antigen

M2-7C10, CK-MM

Melanotic Schwannoma; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Papillary Tumor of the Pineal Region

Melan-A103

clone of Melan-A

A103

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

Merlin

NF1 tumor suppressor gene, encodes for the merlin/schwannomin protein, which is responsible for the inherited disease neurofibromatosis 2

Anti-merlin, neurofibromatosis 2

Meningioma; Neurofibromatosis 2

met

met proto-oncogene

8F11, C-28, C-MET

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma)

MGMT

methylguanine DNA methyltransferase

O-6-methylguanine-DNA methyltransferase, MT3.1

Glioblastoma; Pituitary Blastoma; Pituitary Carcinoma

Myelin basic protein

major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system

Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination)

Myogenin

F5D, MYF3, MYF4, MYOGENIN, LO26

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Peripheral Primitive Neuroectodermal Tumor (Ewing Sarcoma); Pineal Anlage Tumor

Nerve growth factor

NGF

Pituitary Adenoma

Nerve growth factor receptor

growth receptors with specificity to neurotrophins; 2 classes of nerve growth factor receptors include Trk and p75

NGFR

Pituitary Adenoma

Nestin

neural stem cell marker

neural stem cell marker

Tuberous Sclerosis Complex

NeuN

neural stem cell marker

10C2

Central Neurocytoma; CNS Primitive Neuroectodermal Tumors; Cortical Dysplasia; Dysembryoplastic Neuroepithelial Tumor; Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease); Extraventricular Neurocytoma; Ganglion Cell Tumors; Rosette-Forming Glioneuronal Tumor of the 4th Ventricle

NeuroD1

neurogenic differentiation factor 1; transcription factor

BHF, NIDDM, Neuro D, N-19, NEURO D1

Plurihormonal Adenoma

Neurofilament protein

neurofilament H/M phosphorylated protein

TPNFP-1A3, SMI31, SMI33, NFP, SMI32, TA-51, 2F11

Anaplastic Astrocytoma; Anaplastic Ependymoma; Atypical Teratoid/Rhabdoid Tumor; Cellular Schwannoma; CNS Primitive Neuroectodermal Tumors; Cortical Dysplasia; Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Diffuse Astrocytoma; Dysembryoplastic Neuroepithelial Tumor; Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease); Extraneural Neurofibroma Variants; Ganglion Cell Tumors; Hypothalamic Hamartoma; Intraneural Perineurioma; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Medulloblastoma; Papillary Glioneuronal Tumor; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Pituicytoma; Plexiform Schwannoma; Soft Tissue Perineurioma; Subependymal Giant Cell Astrocytoma; Subependymoma

Neurophysin

soluble carrier/transport protein secreted in the hypothalamus

Pituitary Adenoma

NFP

neurofilament H/M phosphorylated protein

TPNFP-1A3, SMI31, SMI33, NFP, SMI32, TA-51, 2F11, neurofilament protein

Anaplastic Astrocytoma; Atypical Teratoid/Rhabdoid Tumor; CNS Primitive Neuroectodermal Tumors; Conventional Schwannoma; Cortical Dysplasia; Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Diffuse Astrocytoma; Dysembryoplastic Neuroepithelial Tumor; Embryonal Tumor with Abundant Neuropil and True Rosettes; Extraneural Neurofibroma Variants; Extraventricular Neurocytoma; Infarct; Intraneural Perineurioma; Malignant Peripheral Nerve Sheath Tumor; Pilocytic Astrocytoma; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Plexiform Neurofibroma; Progressive Multifocal Leukoencephalopathy; Subependymal Giant Cell Astrocytoma

NSE

neuron specific enolase

BSS/H14

Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma)

Nuclear p53

p53 tumor suppressor gene protein

DO7, 21N, BP53-12-1, AB6, CM1, PAB1801, DO1, BP53-11, PAP240, RSP53, MU195, P53

Anaplastic Astrocytoma; Cortical Dysplasia; Diffuse Astrocytoma; Oligodendroglioma; Progressive Multifocal Leukoencephalopathy

OCT1

octamer-binding transcription factor 1

12F11

Germinoma

OCT4

octamer-binding transcription factor-3

OCT3, POU5F1 (OCT3/4), C-10

Atypical Teratoid/Rhabdoid Tumor; Germinoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Other Germ Cell Tumors; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Teratomas

Olig2

oligodendrogliocyte transcription factor 2; transcription factor required for oligodendrocyte and motor neuron development

Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination); Diffuse Astrocytoma; Tuberous Sclerosis Complex

p16

cyclin dependent kinase 4 inhibitor A

Cyclin dependent kinase inhibitor p16 antibody, INK4, INK4a, MLM, MTS1, multiple tumor suppressor 1 antibody, p12, p14, p16 γ, p16 INK4, p16 INK4a, INK4 p19, TP16, P16_INK4A, E6H4, sc1661, JC8, ZJ11, G175-405, F-12, DCS-50, 6H12, 16P07, 16P04

Pituitary Adenoma

p18

Cyclin dependent kinase 4 inhibitor C

P18_INK4C, 118.2

Pituitary Adenoma

p27

cyclin dependent kinase inhibitor 1B

P27_KIP1, 57, 1B4, DCS-72.F6, SX53G8, P27, K25020, DCS72, KIP-1

Malignant Peripheral Nerve Sheath Tumor; Pituitary Adenoma; Pituitary Blastoma; Pituitary Carcinoma

p53

p53 tumor suppressor gene protein

DO7, 21N, BP53-12-1, AB6, CM1, PAB1801, DO1, BP53-11, PAB240, RSP53, MU195, P53

Anaplastic Astrocytoma; Choroid Plexus Carcinoma; Choroid Plexus Papilloma and Atypical Papilloma; Cortical Dysplasia; Diffuse Astrocytoma; Glioblastoma; Gliosarcoma; Granular Cell Astrocytoma of the Cerebrum; Intraneural Perineurioma; Malignant Glioneuronal Tumors; Mixed Oligoastrocytoma; Oligodendroglioma; Osteocartilaginous Neoplasms; Pituitary Adenoma; Pituitary Blastoma; Pituitary Carcinoma; Plexiform Neurofibroma; Plurihormonal Adenoma; Progressive Multifocal Leukoencephalopathy; Prolactinoma

p63

tumor protein p63

H-137, 7JUL

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

pax-2

paired box gene 2

Z-RX2, PAX-2

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

pax-8

paired box gene 8

PAX-8

Hemangioblastoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges

Phospho-AKT

serine/threonine protein kinase

P-AKT

Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease)

Phospho-S6

phosphorylated S6 ribosomal protein, phospho-S6rp; S6 protein of the 40S ribosomal subunit

Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease)

PIT-1

pituitary specific transcription factor

Plurihormonal Adenoma; Somatotroph Adenoma

Pituitary specific transcription factor

PIT-1

Pituitary Adenoma

Placental alkaline phosphatase

PLAP, 228M, 8A9, 88B

Germinoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma)

PLAP

placental alkaline phosphatase

228M, 8A9, 88B

Atypical Teratoid/Rhabdoid Tumor; Germinoma

PRL

prolactin

Lymphocytic Hypophysitis; Pituitary Adenoma; Pituitary Carcinoma; Pituitary Hyperplasia; Plurihormonal Adenoma; Prolactinoma; Somatotroph Adenoma; Thyrotroph Adenoma

Prolactin

PRL

Null Cell Adenoma; Pituitary Adenoma; Pituitary Carcinoma; Pituitary Hyperplasia; Prolactinoma

Prostatic acid phosphatase

Secondary Neoplasms of the Pituitary and Sellar Region

PRP

progesterone receptor protein

PR, 10A9, PGR-1A6, KD68, PGR-ICA, PRP-P, PRI, 1A6, 1AR, HPRA3, PGR-636, 636, PR88, NCLPGR

Meningioma

PTEN

phosphatase and tensin homolog

PN37

Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease); Glioblastoma

S100

Low molecular weight protein normally present in cells derived from neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes

S-100, A6, 15E2E2, Z311, 4C4.9, S100 protein

Atypical Teratoid/Rhabdoid Tumor; Cellular Schwannoma; Conventional Schwannoma; Dysembryoplastic Neuroepithelial Tumor; Ependymoma; Erdheim-Chester Disease; Extraneural Neurofibroma Variants; Fibrosarcoma; Ganglion Cell Tumors; Granular Cell Tumor of Infundibulum; Intraneural Perineurioma; Langerhans Cell Histiocytosis; Localized Intraneural Neurofibroma; Lymphocytic Hypophysitis; Malignant Glioneuronal Tumors; Malignant Peripheral Nerve Sheath Tumor; Melanotic Schwannoma; Meningeal Response to Intracranial Hypotension; Meningioma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Osteocartilaginous Neoplasms; Paraganglioma of the Filum Terminale; Pituicytoma; Plexiform Neurofibroma; Plexiform Schwannoma; Primary Central Nervous System Lymphoma; Primary Melanocytic Neoplasms; Rosai-Dorfman Disease; Schwannomatosis; Soft Tissue Perineurioma; Solitary Fibrous Tumor; Spindle Cell Oncocytoma; Tuberous Sclerosis Complex

SALL4

sal-like protein 4; zinc finger transcription factor

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

Serotonin

5-hydroxytryptamine, a monoamine neurotransmitter

5-HT, 5HT-H209

Ganglion Cell Tumors

SF1

steroidogenic factor-1

AD4BP

Gonadotroph Adenoma

Somatostatin

somatotropin release-inhibiting factor

Ganglion Cell Tumors; Hypothalamic Hamartoma; Paraganglioma of the Filum Terminale; Pituitary Adenoma; Subependymal Giant Cell Astrocytoma

Somatostatin receptor

group of G-protein coupled transmembrane receptors

somatostatin-R

Pituitary Adenoma

Substance-P

neuropeptide, functions as a neurotransmitter and as a neuromodulator

Subependymal Giant Cell Astrocytoma

SV40

simian virus 40

Anaplastic Astrocytoma; Intravascular Lymphomatosis; Progressive Multifocal Leukoencephalopathy

Synaptophysin

major synaptic vesicle protein p38 antibody

SVP38, SY38, SNP-88, SYP, SYPH, Sypl, Syn p38

Anaplastic Astrocytoma; Anaplastic Ependymoma; Anaplastic Oligodendroglioma; Atypical Teratoid/Rhabdoid Tumor; Central Neurocytoma; Cerebellar Liponeurocytoma; Choroid Plexus Carcinoma; Choroid Plexus Papilloma and Atypical Papilloma; Desmoplastic Infantile Ganglioglioma; Dysembryoplastic Neuroepithelial Tumor; Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease); Embryonal Tumor with Abundant Neuropil and True Rosettes; Endodermal Cyst; Ependymoma; Extraventricular Neurocytoma; Ganglion Cell Tumors; Germinoma; Glioblastoma; Gonadotroph Adenoma; Granular Cell Tumor of Infundibulum; Hypothalamic Hamartoma; Lymphocytic Hypophysitis; Malignant Glioneuronal Tumors; Medulloblastoma; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Mixed Oligoastrocytoma; Null Cell Adenoma; Oligodendroglioma; Papillary Glioneuronal Tumor; Papillary Tumor of the Pineal Region; Paraganglioma of the Filum Terminale; Peripheral Primitive Neuroectodermal Tumor (Ewing Sarcoma); Pilocytic Astrocytoma; Pilomyxoid Astrocytoma; Pineal Anlage Tumor; Pineal Cyst; Pineal Parenchymal Neoplasms (Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation, and Pineoblastoma); Pituicytoma; Pituitary Adenoma; Pituitary Blastoma; Pituitary Carcinoma; Pleomorphic Xanthoastrocytoma; Primary Central Nervous System Lymphoma; Rosette-Forming Glioneuronal Tumor of the 4th Ventricle; Secondary Neoplasms of the Pituitary and Sellar Region; Spindle Cell Oncocytoma; Subependymal Giant Cell Astrocytoma; Subependymoma; Teratomas; Tuberous Sclerosis Complex

T. whipplei

Tropheryma whipplei, formerly called Tropheryma whippelii; causative organism of Whipple disease

Whipple Disease

TAU

microtubule-associated protein of axons AT8

Ganglion Cell Tumors; Meningioangiomatosis

Thyroglobulin

dimetric protein specific to thyroid gland

DAK-TG6

Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

Thyroid peroxidase

TPO, TPO47

Lymphocytic Hypophysitis

TLE1

transducer-like enhancer 1

Malignant Peripheral Nerve Sheath Tumor

Toxoplasma gondii

Parasitic protozoan, causative organism of toxoplasmosis

Toxoplasmosis

Transforming factor alpha

member of the epidermal growth factor family of cytokines

TGF-α, TGF-Alpha, 213-4.4,

Pituitary Adenoma

Transthyretin

carrier protein of thyroxin and retinol; rich in a beta sheet structure

prealbumin

Choroid Plexus Papilloma and Atypical Papilloma

TRAP

tartrate-resistant acid phosphatase

26E5, 9C5

Atypical Teratoid/Rhabdoid Tumor; Pilocytic Astrocytoma; Somatotroph Adenoma

TSH

thyroid stimulating hormone

beta-TSH

Adamantinomatous Craniopharyngioma; Pituitary Adenoma; Pituitary Carcinoma; Pituitary Hyperplasia; Plurihormonal Adenoma; Thyrotroph Adenoma; Somatotroph Adenoma

TTF-1

transcription termination factor

8G7G3/1, SPT-24, SC-13040

Choroid Plexus Carcinoma; Granular Cell Tumor of Infundibulum; Metastatic Neoplasms, Intracranial and Intraspinal Meninges; Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord; Pituicytoma; Secondary Neoplasms of the Pituitary and Sellar Region; Spindle Cell Oncocytoma

Tubulin

globular proteins that make up microtubules

Dysembryoplastic Neuroepithelial Tumor

Tyrosinase

catalyzes production of melanin

NCL-TYROS, T311

Melanotic Schwannoma; Papillary Tumor of the Pineal Region; Primary Melanocytic Neoplasms

Tyrosine hydroxylase

TYH, TYR HYDROXY

Ganglion Cell Tumors

Ubiquitin

Small regulatory protein that binds proteins and labels them for destruction

Ganglion Cell Tumors

Vascular endothelial growth factor

VEGF, JH121, 26503.11, VPF, VPF/VEGF, VEGFA, VEGF-C, RP 077, VEGFR-1, RP 076, VEGFR-2, 9D9, VEGFR-3, FLT-4

Pituitary Adenoma

Vasoactive intestinal peptide

VIP

Ganglion Cell Tumors

Vasopressin

arginine vasopressin (AVP), argipressin, or antidiuretic hormone (ADH); increases water absorption in the collecting ducts of the kidney nephron

Pituicytoma; Pituitary Adenoma

Vimentin

major subunit protein of the intermediate filaments of mesenchymal cells

43BE8, 3B4, V10, V9, VIM-3B4, VIM

Atypical Teratoid/Rhabdoid Tumor; Granular Cell Tumor of Infundibulum; Melanotic Schwannoma; Meningioma; Osteocartilaginous Neoplasms; Pituicytoma; Pituitary Blastoma; Smooth Muscle Neoplasms; Spindle Cell Oncocytoma; Teratomas; Tuberous Sclerosis Complex

WT1

Wilms tumor gene-1

6F-H2, C-19

Metastatic Neoplasms, Intracranial and Intraspinal Meninges