Antibody and Molecular Factor Index



Antibody and Molecular Factor Index













Antibodies Discussed























































































































































































































































































































































Antibody Name/Symbol


Antibody Description


Clones/Alternative Names


Chapters


β-catenin


beta catenin; involved in regulation of cell adhesion and in signal transduction through Wnt pathway


B-catenin, CLONE 14, E-5, RB-9035Po, 17C2, 5H10


Nodular Fasciitis


Actin-sm


actin, smooth muscle


SMA, ASM-1, CGA7, 1A4, HUC1-1


Nodular Fasciitis


AE1/AE3


mixture of 2 anticytokeratin clones that detect a variety of both high and low molecular weight cytokeratins



Rheumatoid Nodule


Bartonella henselae



anti-Bartonella henselae (cat scratch disease) antibody


Cat Scratch Disease/Bacillary Angiomatosis


Basic fibroblast growth factor



FGF2, BFGF, BASIC FGF


Stasis Dermatitis


BAX


Bcl-2-associated X protein


PU-347-P, B-9, BAX-P, P19, BAX-M


Darier Disease


Bcl-2


B-cell lymphoma 2; suppresses apoptosis in a variety of cell systems


ONCL2, BCL2/100/D5, 124, 124.3


Darier Disease


Bcl-x


member of the BCL-2 family of proteins that functions in the regulation of apoptosis


BCL-X1; BCL-XL; 2H12


Darier Disease


BP180


transmembrane protein of the cutaneous basement membrane that plays an important role in epidermal-dermal adhesion


bullous pemphigoid antigen 180, Collagen XVII


Cicatricial Pemphigoid; Linear IgA Disease; Pemphigoid Gestationis


BPAg-1


180 kDa type II transmembrane protein associated with hemidesmosomes in basal keratinocytes


bullous pemphigoid antigen 1, BPAG1


Epidermolysis Bullosa Acquisita


Caldesmon


actin-interacting and calmodulin-binding protein found in smooth muscle and other cell types



Nodular Fasciitis


Calponin


thin filament-associated protein that is implicated in regulation and modulation of smooth muscle contraction


N3, 26A11, CALP, CNN1, SMCC, Sm Calp


Nodular Fasciitis


CCL17


thymus and activation regulated chemokine


TARC


Atopic Dermatitis


CD1a


T-cell surface glycoprotein


JPM30, CD1A, O10, NA1/34


Lichen Nitidus; Transient Neonatal Pustular Melanosis


CD3


T-cell receptor


F7238, A0452, CD3-P, CD3-M, SP7, PS1


Lyme Disease and Its Manifestations


CD4


T-cell surface glycoprotein, L3T4


IF6, 1290, 4B12, 1F6, CD04


Aspergillosis; Atypical Mycobacterial Infections; Cryptococcosis; Morbilliform Drug Reactions; Psoriasis; Rhinoscleroma; Sarcoidosis; Sporotrichosis


CD8


T-cell coreceptor antigen, Leu 2, T-cytotoxic cells


M7103, C8/144, C8/144B


Morbilliform Drug Reactions; Sarcoidosis


CD20


glycosylated phosphoprotein expressed on the surface of B cells


BER-H2, KI-1, TNFRSF8


Lyme Disease and Its Manifestations


CD25


If-2 receptor alpha


2A3, 4C9


Fixed Drug Eruption


CD31


platelet endothelial cell adhesion molecule


JC/70, JC/70A, PECAM-1


Nodular Fasciitis


CD34


cell surface glycoprotein that functions in cell to cell adhesion in stem and stromal cells


MY10, IOM34, QBEND10, 8G12, 1309, HPCA-1, NU-4A1, TUK4, clone 581, BI-3c5


Nodular Fasciitis


CD54


ICAM-1 (intracellular adhesion molecule 1)


23G12, CD54-P, ICAM


Morbilliform Drug Reactions


CD56


NCAM (neutral cellular adhesion molecule)


MAB735, ERIC-1, 25-KD11, 123C3, 24-MB2, BC56C04, 1B6, 14-MAB735, NCC-LU-243, MOC-1, NCAM


Granulomatosis with Polyangiitis


CD68


cytoplasmic granule protein of monocytes, macrophages


PG-M1, KP-1, LN5


Nodular Fasciitis


CK-PAN


cytokeratin-pan (AE1/AE3/LP34); cocktail of high and low molecular weight cytokeratins


keratin pan, MAK-6, K576, LU-5, KL-1, KC-8, MNF 116, pankeratin, pancytokeratin


Nodular Fasciitis


CMV


Cytomegalovirus



Cytomegalovirus; Drug Rash with Eosinophilia and Systemic Symptoms (DRESS)


Collagen II


major component of articular and hyaline cartilage


2B1.5


Lipoid Proteinosis


Collagen IV


major constituent of the basement membranes along with laminins, proteoglycans, and enactins


CIV22, COL4A [1-5], collagen α-1(IV) chain


Lipoid Proteinosis; Perforating Dermatoses; Porphyria Cutanea Tarda


Desmin


class III intermediate filaments found in muscle cells


M760, DE-R-11, D33, DE5, DE-U-10, ZC18


Nodular Fasciitis


Desmoplakin


desmosome-associated protein that functions in intercellular junctions



Darier Disease; Pemphigus and Variants


EAB903


cytokeratin, high molecular weight (34bE12, CK 1, 5, 10, 14)


34b312, MA-903, CK903


Amyloidosis


EBER


Epstein-Barr virus encoded RNA



Epstein-Barr Virus Infections


EGFR


v-erb b1 erythroblastic leukemia viral gene, epidermal growth factor receptor


2-18C9, EGFR1, EGFR PHRMDX, NCL-R1, H11, C-ERBB-1, E30, EGFR.113, 31G73C6, 2-18C9


Folliculitis


EKH4


monoclonal antikeratin antibody; antigen specificity is toward keratin (50 KD)



Amyloidosis


EMA


epithelial membrane antigen


EMA, GP1.4, 214D4, MC5, E29, MUC1, LICRLON- M8, BC3, DF3, VU3D1, MUSEII, RD-1, MA695, MA552, PS2P446, 115D8, MUC1, MAM6, CA15.3, MUC01


Rheumatoid Nodule


Epidermal growth factor



EGF, KME-10


Folliculitis


Epidermal growth factor receptor


v-erb b1 erythroblastic leukemia viral gene, epidermal growth factor receptor


EGFR, 2-18C9, EGFR1, EGFR PHRMDX, NCL-R1, H11, C-ERBB-1, E30, EGFR.113, 31G73C6, 2-18C9


Folliculitis


Factor XIIIa


fibrin stabilizing factor


FXIIIA


Multicentric Reticulohistiocytosis


FAS


fatty acid synthase


CD95/fas


Erythema Multiforme


Filaggrin


filament-associated protein that binds to keratin in epithelial cells


FLG


Atopic Dermatitis; Granular Parakeratosis; Ichthyosis


GM-CSF


granulocyte macrophage colony stimulating factor


3209.1


Atopic Dermatitis


Granulocyte colony stimulating factor


granulocyte macrophage colony stimulating factor


3209.1, GM-CSF


Neutrophilic Eccrine Hidradenitis; Sweet Syndrome


HSV1


herpes simplex virus 1



Herpesvirus


IgA


immunoglobulin A


IGA


Atopic Dermatitis; Dermatitis Herpetiformis; Epidermolysis Bullosa Acquisita; Leukocytic Vasculitis and Variants; Lichen Nitidus; Lichen Planus; Linear IgA Bullous Dermatosis; Bullous Pemphigoid; Pemphigus and Variants; Perforating Dermatoses; Porphyria Cutanea Tarda; Relapsing Polychondritis; Subcorneal Pustular Dermatosis


IgG


immunoglobulin G


IGG


Annular Erythemas; Cicatricial Pemphigoid; Dermatitis Herpetiformis; Epidermolysis Bullosa Acquisita; Hailey-Hailey Disease; Impetigo; Lichen Myxedematosus; Lichen Planus; Linear IgA Bullous Dermatosis; Lupus Erythematosus and Variants; Bullous Pemphigoid; Pemphigoid Gestationis; Pemphigus and Variants; Polymorphous Light Eruption; Porphyria Cutanea Tarda; Staphylococcal Scalded Skin Syndrome; Subcorneal Pustular Dermatosis


IgM


immunoglobulin M


IGM


Amyloidosis; Annular Erythemas; Dermatitis Herpetiformis; Epidermolysis Bullosa Acquisita; Lichen Nitidus; Lichen Planus; Lichenoid Keratosis; Linear IgA Bullous Dermatosis; Polymorphous Light Eruption; Pruritic Urticarial Papules and Plaques of Pregnancy; Reticular Erythematous Mucinosis; Urticaria and Variants


IL-1


involved in the inflammatory response, being identified as endogenous pyrogens



Leukocytic Vasculitis and Variants


IL-13


interleukin 13



Psoriasis


IL-15


interleukin 15



Fixed Drug Eruption


Immunoglobulin A



IGA, IgA


Porphyria Cutanea Tarda


Intermediate filament


neurofilament triplet protein



Amyloidosis


Kappa


kappa light chain


KAPPA, κ light chain


Amyloidosis; Lyme Disease and Its Manifestations


Lambda


lambda light chain


λ light chain, LAMBDA


Amyloidosis; Lyme Disease and Its Manifestations


Laminin


major protein in basal lamina


LAMININ-4C7, 4C12.8, LAM-89


Cicatricial Pemphigoid; Epidermolysis Bullosa (Inherited); Lipoid Proteinosis


Laminin 5


component of epithelial cell basement membranes


Antiepiligrin


Cicatricial Pemphigoid


MAC387


macrophage antibody



Dermatomyositis


Melan-A


melanoma antigen recognized by T cells 1 (MART-1); protein found on melanocytes; melanocyte differentiation antigen


M2-7C10, CK-MM


Lichenoid Keratosis


met


met proto-oncogene



Lupus Erythematosus and Variants


Perforin



P1-8, PE-41-PU, 5B10


Graft vs. Host Disease; Morbilliform Drug Reactions


S100


low molecular weight protein normally present in cells derived from neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes


S-100, A6, 15E2E2, Z311, 4C4.9


Lichen Nitidus; Nodular Fasciitis; Prurigo Nodularis; Transient Neonatal Pustular Melanosis; Juvenile Xanthogranuloma


Somatostatin




Necrolytic Migratory Erythema


Tissue plasminogen activator


serine protease that catalyzes the conversion of plasminogen to plasmin


TPA, tPA, PLAT


Livedoid Vasculopathy


TNF-α


cytokine involved in systemic inflammation, stimulates the acute phase reaction


Gamma catenin, y-catenin, G-catenin, alpha alpha, TNF, cachexin, cachectin


Cicatricial Pemphigoid; Fixed Drug Eruption; Graft vs. Host Disease; Hidradenitis Suppurativa; Morbilliform Drug Reactions; Necrobiosis Lipoidica; Pityriasis Rubra Pilaris; Psoriasis


Transthyretin


carrier protein of thyroxin and retinol; rich in a beta sheet structure


Prealbumin


Amyloidosis


V-Alpha


T-cell antigen receptor alpha chain


TCR-α


Relapsing Polychondritis


V-Beta 11


Antibody directed toward the beta chain of the TCR-αβ heterodimer


TCR-β


Relapsing Polychondritis


Vimentin


major subunit protein of intermediate filaments of mesenchymal cells


43BE8, 3B4, V10, V9, VIM-B34, VIM


Granuloma Faciale; Nodular Fasciitis

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Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Antibody and Molecular Factor Index
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