PATHOLOGY & LABORATORY MEDICINE

Condyloma Acuminatum (Genital Wart)

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Condyloma Acuminatum (Genital Wart)

 Irregular wrinkled nuclei  Bi- and multinucleation  Perinuclear vacuolization • Old lesions may mimic seborrheic keratoses Ancillary Tests • Immunostain for p16 is negative (there is no overexpression) • In situ hybridization and PCR…

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Granular Cell Tumor

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Granular Cell Tumor

 Female predilection  More prevalent in African Americans • Wide anatomic distribution, usually arises in skin and subcutaneous tissue  Head and neck region common (tongue, oral cavity) • Usually solitary, painless nodule, plaque,…

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Leiomyosarcoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Leiomyosarcoma

 Lesions restricted to cutis only rarely metastasize Microscopic • Perpendicularly oriented fascicles of spindle cells • Brightly eosinophilic cytoplasm • Blunt-ended nuclei • Nuclear atypia and mitoses Ancillary Tests • Labels as per smooth muscle:…

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Acral Lentiginous Melanoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Acral Lentiginous Melanoma

 Rare to absent in early lesions, prominent and confluent in late lesions  Nests are irregular in size and shape, randomly alternate with single melanocytes • Cells show elongated, ovoid hyperchromatic nuclei…

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Desmoplastic Melanoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Desmoplastic Melanoma

 HMWCKs(+), p63; S100(-) • Atypical fibroxanthoma  S100(-); CD10/CD68/CD99 (+) • Dermatofibroma: FXIIIA/CD10 (+); S100(-) • Dermatofibrosarcoma protuberans: CD34(+); S100(-) • Neural tumors  S100/SOX10 (+); CD34(+) (not in DM) • Leiomyosarcoma  Actin/desmin (+), S100(-) Scar-Like Appearance…

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Cutaneous Gamma-Delta T-Cell Lymphoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Cutaneous Gamma-Delta T-Cell Lymphoma

 Malignant T cells rim around adipocytes  Prominent karyorrhexis/apoptosis and angioinvasion Ancillary Tests • Immunohistochemistry: TCRδ1(+), βF1(-), CD56(+), CD4(-), CD8(-) • EBER(-), cytotoxic markers (+) • T-cell receptor gene rearrangement Top Differential Diagnoses • Subcutaneous…

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Leiomyoma (Pilar)

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Leiomyoma (Pilar)

 Pilar type (piloleiomyoma) arises from arrector pili  Genital type arises from specialized genital smooth muscle Etiology/Pathogenesis • Hereditary leiomyomatosis and renal cell cancer syndrome  Multiple leiomyomas of skin and uterus  Subset…

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Neuromas

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Neuromas

 Solitary circumscribed neuroma (“palisaded encapsulated neuroma”) represents spontaneous proliferation of peripheral nerve fibers  Multiple mucosal neuromas associated with multiple endocrine neoplasia syndrome (type 2B) represents rare autosomal dominant condition  Traumatic…

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Myxoinflammatory Fibroblastic Sarcoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Myxoinflammatory Fibroblastic Sarcoma

 Inflammatory component shows variable mixtures of lymphoplasmacytic cells, eosinophils, neutrophils, and histiocytes • Areas with prominent myxoid change • Scattered enlarged atypical tumor cells, some with macronucleoli  Cells with macronucleoli resemble Reed-Sternberg…

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