PATHOLOGY & LABORATORY MEDICINE

Soft Tissue Chondroma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Soft Tissue Chondroma

 Range: 0.3-6.5 cm Microscopic • Well circumscribed and lobulated • Mostly composed of mature hyaline cartilage • Variable amounts of calcification • Ossification common • Granulomatous inflammation in 15% of cases • Rare tumors with extensive…

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Glomus Tumors

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Glomus Tumors

 Considered to fall on morphologic spectrum with myopericytoma, myofibroma, and angioleiomyoma Clinical Issues • Most common in young adults (20-40 years) • Female predilection in subungual tumors • Most common in distal extremities…

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Melanoma In Situ, Not Otherwise Specified

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Melanoma In Situ, Not Otherwise Specified

 Cells are markedly enlarged and atypical to bizarre-appearing Top Differential Diagnoses • Melanoma in situ, superficial spreading type • Melanoma in situ, lentigo maligna type • Atypical (dysplastic) junctional melanocytic nevus • Irritated/traumatized nevi…

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PEComas

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on PEComas

 Includes angiomyolipoma (AML), clear cell sugar tumor of lung (CCST), lymphangioleiomyomatosis (LAM), clear cell myomelanocytic tumor of falciform ligament/ligamentum teres Etiology/Pathogenesis • Only AML, CCST, and LAM are associated with tuberous…

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Spitz (Spindle and Epithelioid Cell) Nevi

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Spitz (Spindle and Epithelioid Cell) Nevi

 Spindle cells much more common  Epithelioid cells usually dispersed individually throughout lesion • Melanocytes “mature” by becoming smaller from superficial to deep • Kamino bodies: Eosinophilic globules at dermal-epidermal junction • Artifactual clefting…

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Branchial Cleft Cyst

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Branchial Cleft Cyst

 Enlarges after upper respiratory tract infection • Along anterior border of sternocleidomastoid muscle • Initial work-up of suspected branchial cleft anomaly (in order)  Intravenous or oral antibiotics (if infected), FNA, endoscopy &/or…

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Spindle Cell/Pleomorphic Lipoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Spindle Cell/Pleomorphic Lipoma

 Variable admixture of bland spindle cells, ropey collagen, mature adipose tissue, myxoid stroma, and mast cells • PL contains multinucleated tumor cells • Morphologic variants: Fat-free, fat-poor, angiomatous Ancillary Tests • CD34(+); loss…

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Adult T-Cell Leukemia/Lymphoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Adult T-Cell Leukemia/Lymphoma

 Epidermotropism &/or Pautrier microabscesses • Peripheral blood with multilobated “flower cells” • Lymph nodes with effaced architecture & diffuse infiltrate • Bone marrow with patchy involvement & increased osteoclasts Ancillary Tests • Confirmation of…

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Trichoblastoma

Apr 24, 2017 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Trichoblastoma

 Can be multiple in some cases • Rare recurrences and association with, or progression to, malignancy [basal cell carcinoma (BCC)] Macroscopic • Nodular lesion involving deep dermis and subcutis • Large, typically >…

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