Calcified Fibrous Pseudotumor



Calcified Fibrous Pseudotumor











Low-power view shows a calcifying fibrous pseudotumor of the pleura. Note the presence of numerous calcifications image embedded in a fibrous stroma with mild inflammatory changes.






The tumor is composed of a bland spindle cell proliferation image with scattered inflammatory cells and the presence of psammomatous calcifications image.


TERMINOLOGY


Abbreviations



  • Calcified fibrous pseudotumor (CFPT)


Definitions



  • Benign fibrocollagenous tumor with dystrophic or psammomatous calcifications


ETIOLOGY/PATHOGENESIS


Possible Etiologies



  • Fibroinflammatory in nature


  • Reactive process


  • Late sclerosing stage of myofibroblastic tumor


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Very uncommon tumor in thoracic cavity


  • Age



    • Usually occurs in adults from 20-55 years old


  • Gender



    • No gender predilection


Presentation



  • Cough


  • Chest pain


  • Shortness of breath


  • Asymptomatic


Treatment



  • Surgical approaches



    • Complete surgical resection


Prognosis



  • Good


  • Recurrences may occur


MACROSCOPIC FEATURES


General Features



  • Single pleural mass


  • Multiple pleural nodules


Size



  • Tumors may vary from 1 cm to > 10 cm in diameter


MICROSCOPIC PATHOLOGY


Histologic Features



  • Dense fibrocollagenous tissue


  • Psammoma bodies


  • Dystrophic calcifications


  • Lymphoplasmacytic inflammatory reaction


  • Absence of nuclear atypia or mitotic activity


  • Absence of necrosis &/or hemorrhage


Predominant Pattern/Injury Type



  • Fibrous

Jul 9, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Calcified Fibrous Pseudotumor

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